Unfolding through a course of a night in Mumbai, Kaalakaandi showcases three parallel tracks — a man who discovers he has terminal illness decides to let go of his principles and live a little; a woman involved in a hit-and-run seeks redemption and two goons must decide if they can trust each other.

Mumbai, 2015. Raghav, a drug addict policeman who maintains a turbulent relationship with his girlfriend Simmy, and Raman, a serial killer obsessed with Raman Rhagav's heinous crimes, a notorious psychopath convicted in 1969, get caught in a ruthless cat-and-mouse game, a dark path with no return for both of them.